The 9 Best Luxury Hotels with Spa in Salta Wine Route (2025)

Nestled in the breathtaking foothills of the Andes, the Salta Wine Route is a captivating blend of rich culture, stunning landscapes, and world-class vineyards. This enchanting region, renowned for its vibrant colonial architecture and lively markets, invites visitors to explore charming towns like Cafayate and its picturesque plazas. As you sip on the region's exquisite Torrontés or Malbec, you'll discover that the luxury hotel scene here is equally exceptional. Indulge in exclusive stays at Piattelli Wine Resort Hotel Cafayate, where breathtaking vineyard views complement lavish accommodations and personalized service. The House of Jasmines Relais & Châteaux offers a unique blend of rustic elegance and modern comfort, inviting guests to unwind amidst sprawling gardens and gourmet dining experiences. Meanwhile, Grace Cafayate stands out for its contemporary design and opulent amenities, including a world-class spa that promises ultimate relaxation. Embark on an unforgettable journey along the Salta Wine Route and explore our collection of Salta luxury hotels with spa offerings that cater to every discerning traveler’s desire. Start planning your getaway today!

Top Luxury Hotels in Salta Wine Route

luxury hotels in Salta Wine Route

Piattelli Wine Resort Hotel Cafayate

Resort
Camino a Yacochuya Km 3., 4427 Cafayate, Argentina

Nestled in the breathtaking embrace of Cafayate's sun-kissed valleys, Piattelli Wine Resort Hotel invites you to indulge in a harmonious blend of luxury and nature. With stunning mountain views framing your every moment, this elegant retreat seamlessly marries modern comfort with the rustic charm of its vineyard surroundings, creating an intimate sanctuary for romance seekers and wellness enthusiasts alike.

Total Relaxation - Unwind in the resort's luxurious spa, where the soothing sounds of rustling leaves mingle with the gentle trickle of water from nearby fountains. Enjoy a rejuvenating massage or take a dip in the outdoor pool, surrounded by panoramic vistas that invite you to linger longer in bliss.

Romantic Getaway - Every detail at Piattelli Wine Resort whispers romance—from private balconies overlooking lush vineyards to candlelit dinners at the chic clubhouse. Revel in the soft glow of sunset as you sip exquisite local wines, crafting memories that will linger in your heart long after the evening ends.

Outstanding Location - Explore the enchanting landscapes dotted with world-class wineries just beyond your doorstep, perfect for a day of tasting and adventure. Delight in leisurely strolls through charming local markets, where the aroma of fresh produce and artisanal goods beckons you to savor the essence of Argentine culture.

Guest Experiences - You can almost taste the warm, inviting aroma of freshly baked bread wafting through the air during breakfast, complemented by the cheerful chatter of fellow guests sharing plans for the day. A delightful surprise awaits as you spot a playful bodega cat lounging at the entrance, adding a whimsical touch to your idyllic stay.

luxury hotels in Salta Wine Route

House of Jasmines Relais & Châteaux

Hotel
Ruta Nacional 51 km 6, 4407 El Encón, Argentina

Nestled in the enchanting landscapes of El Encón, Argentina, House of Jasmines Relais & Châteaux offers a serene escape where rustic elegance meets modern luxury. Surrounded by rolling hills and vibrant gardens, this boutique hotel invites couples, honeymooners, and luxury seekers to indulge in intimate moments under the vast Argentine sky.

Chic Accommodations - Each room and suite is a harmonious blend of country charm and contemporary comfort, featuring elegant parquet floors, private terraces with breathtaking mountain views, and sumptuous beds that invite restful slumber after a day of exploration.

Total Relaxation - Unwind at the exquisite spa, where the soothing aromas of essential oils intertwine with the soft sound of rustling leaves, enhancing your experience as you partake in rejuvenating treatments or simply enjoy the tranquility of the sauna and steam room.

Culinary Delights - Savor the rich flavors of local cuisine at the intimate dining room, where freshly cooked breakfast options greet you each morning alongside sweet pastries and fragrant coffees, while dinner showcases locally sourced ingredients paired with superb wines, inviting you to linger over each bite.

Guest Experiences - Imagine starting your day enveloped in the warm aroma of freshly brewed coffee, gently accompanied by birdsong from the lush gardens. As you lounge by the heated pool, glistening under the sun, the tranquil setting feels like your own slice of paradise, enhanced by charming wooden loungers ready for your relaxation.

luxury hotels in Salta Wine Route

Grace Cafayate

Hotel
Ruta Nacional 40, km 4340, 4427, 4427 Cafayate, Argentina

Nestled amidst the sun-drenched vineyards of Cafayate, Grace Cafayate is a sanctuary where luxury meets nature, and romance comes alive against the backdrop of the majestic Andes Mountains. Here, every detail is thoughtfully curated to offer an intimate retreat, enveloping guests in the warmth of Argentine hospitality just a heartbeat away from the vibrant cultural tapestry of the region.

Total Relaxation - Indulge in serenity with both indoor and outdoor pools that invite you to bask in sunlight or stargaze under the vast Andean sky, creating perfect moments of peace and tranquility.

Culinary Journeys - Savor exquisite meals at our gourmet restaurant, where each dish is a celebration of local flavors, complemented by an impressive selection of wines that transport your palate on a journey through Cafayate’s renowned vineyards.

Intimate Escapes - Experience romance in spacious accommodations featuring soft linens and private terraces, where the gentle sounds of the wind rustling through the vines provide a soothing soundtrack to your getaway.

Guest Experiences - One guest recounted the delightful aroma of freshly baked bread wafting through the air during breakfast, while another marveled at how the attentive staff remembered their favorite wine, making them feel like cherished friends rather than mere visitors.

luxury hotels in Salta Wine Route

Hotel Salta

Hotel
Buenos Aires 01, 4400 Salta, Argentina

Nestled in the heart of Salta, Hotel Salta reigns majestically across from the vibrant 9 de Julio Square, enveloping guests in an ambiance where elegance meets history. This neo-classical gem, a proud National Cultural Heritage site, invites couples and adventurers alike to indulge in plush accommodations while savoring breathtaking views and the warm embrace of Argentinian hospitality.

Outstanding Location - Step outside and find yourself enveloped by the rhythm of Salta's lively streets, with museums, restaurants, and cultural treasures just a leisurely stroll away—every corner seems to whisper stories of the past.

Spa Breaks - Rejuvenate your spirit in the serene spa, where soothing aromas mingle with soft melodies, inviting you to unwind while skilled therapists melt away your cares with luxurious treatments designed for total relaxation.

Romantic Retreat - With its stunning panoramic restaurant overlooking the square, every meal transforms into a romantic escape—imagine clinking glasses as golden sunsets bathe the city in warm hues, igniting sparks on special evenings.

Guest Experiences - As you lounge beside the pristine pool, the gentle rustle of palm leaves creates a soothing backdrop while guests share laughter over expertly crafted cocktails, the air rich with the tantalizing scent of fresh juices drifting from the breakfast buffet nearby.

luxury hotels in Salta Wine Route

Alejandro 1º Hotel

Hotel
Balcarce 252, A4400EJF Salta, Argentina

Nestled in the heart of Salta, Alejandro 1º Hotel is an oasis of modern elegance and refined comfort. With stunning views of historical towers and the lush San Bernardo Hill, this upscale retreat invites couples, adventurers, and wellness seekers alike to immerse themselves in its vibrant atmosphere, where luxury meets local charm.

Spa & Relaxation - Indulge in a serene escape at the hotel's lavish spa, where the soothing scents of essential oils mingle with soft melodies from nearby piano chords, inviting you to unwind. Enjoy rejuvenating treatments designed to refresh your body and soul after a day of exploring Salta's rich heritage.

Outstanding Location - Located just steps from the bustling Main Square, Alejandro 1º Hotel allows guests to effortlessly wander through Salta's colorful markets and historic sites. The lively streets hum with the sounds of laughter and music, creating an enchanting backdrop for your urban adventure.

Romantic Break - The intimate atmosphere of Alejandro 1º Hotel sets the stage for unforgettable moments. Savor exquisite meals crafted from locally sourced ingredients while being enveloped in the warm glow of candlelight, making every dinner a cherished memory.

Guest Experiences - Upon arrival, guests are greeted with the rich aroma of freshly baked pastries wafting from the hotel’s restaurant, leaving a delectable first impression. Many have found themselves enchanted by the charming door staff, who not only carry your bags but also share tips about hidden local gems, transforming a simple stay into a tapestry of memorable experiences.

luxury hotels in Salta Wine Route

Hotel Almería

Hotel
Vicente López 146, 4400 Salta, Argentina

Nestled in the vibrant heart of Salta, Hotel Almería invites you into a world of elegance and tranquility. With its charming architecture echoing the history of this enchanting city, each moment spent here feels like a romantic escape, complete with the soothing sounds of nearby streets and the fragrant aromas wafting from local cuisine.

Romantic Break - Indulge in intimate evenings at the hotel's exquisite restaurant, where the gentle ambiance is complemented by delectable regional dishes, perfect for savoring while sharing stories under soft candlelight.

Spa Breaks - Unwind in the luxurious spa, where guests can luxuriate in serene hot tubs and rejuvenating saunas, surrounded by calming scents and the subtle trickle of water — an oasis designed to melt away the stresses of everyday life.

Outstanding Location - With historic landmarks just a leisurely stroll away, immerse yourself in the rich culture of Salta, allowing the whispers of time to guide your exploration through bustling markets and breathtaking views.

Guest Experiences - Many guests have marveled at the warm hospitality of the staff, particularly remarking on the attentive front desk team who offer personalized recommendations, making every visitor feel as if they were returning home.

luxury hotels in Salta Wine Route

Legado Mitico Salta Hotel Boutique

Hotel
Bartolomé Mitre 647, A4400EHM Salta, Argentina

Nestled in the heart of Salta, the Legado Mitico Salta Hotel Boutique invites you to experience an enchanting blend of history and modern elegance. This 1930s gem envelops guests in its captivating charm, where each corner whispers tales of local heritage, offering a sanctuary for couples and cultural explorers alike.

Romantic Break - Indulge in intimate moments within spacious suites adorned with artworks that echo the spirit of celebrated figures from Salta's vibrant past, all while enjoying the gentle breeze on your private balcony.

Boutique Charm - Step into a world where every detail is thoughtfully curated; this boutique hotel exudes warmth and personality, making it a delightful hideaway, complete with cozy shared lounges and a tranquil inner patio kissed by sunlight.

Outstanding Location - With just a leisurely stroll to the historic 9 de Julio Square, you can soak up the rich tapestry of Salta's culture, from lively local markets to intriguing museums, all while returning home to the inviting embrace of your elegant retreat.

Guest Experiences - As dawn breaks, the enticing aroma of freshly brewed coffee wafts through the air, mingling with the sounds of laughter from fellow travelers sharing stories by the fireplace, creating a warm and welcoming atmosphere that feels like home away from home.

luxury hotels in Salta Wine Route

Casa Real Hotel

Hotel
Mitre 669, A4400EHM Salta, Argentina

Nestled in the picturesque embrace of Salta's majestic mountains, Casa Real Hotel emerges as a sanctuary where elegance meets comfort. The moment you step into this refined haven, you're enveloped by a sense of tranquility, accentuated by the soft whispers of the indoor pool and the inviting aroma of freshly brewed coffee wafting through the air.

Outstanding Location - Perfectly positioned just a stroll away from Salta's vibrant heart, guests can effortlessly explore bustling local markets and charming bars while returning to the serene oasis of the hotel at day's end.

Spa Breaks - Indulge your senses in our spa club, featuring a soothing hydromassage tub and a heated indoor swimming pool, where time seems to melt away and relaxation reigns supreme in an atmosphere infused with gentle aromas and soft music.

Romantic Break - With its chic decor and panoramic views of the surrounding mountains, Casa Real Hotel is the ideal backdrop for intimate moments; couples can share quiet evenings overlooking twinkling city lights, creating memories that linger like the warm hues of sunset.

Guest Experiences - One guest recounted the delight of waking up to the enticing scent of homemade pastries during breakfast, while another noted the sheer joy of discovering a cozy nook near the pool, perfect for curling up with a book as sunlight danced on the water.

luxury hotels in Salta Wine Route

Sheraton Salta Hotel

Hotel
Coronel Francisco De Uriondo 330, 4400 Salta, Argentina

Nestled against the stunning backdrop of Lerma Valley, Sheraton Salta Hotel offers a captivating blend of modern elegance and serene luxury. As you step into this oasis, the air is filled with the soft scent of fresh flowers, and the gentle sounds of laughter and relaxation create an inviting atmosphere perfect for couples and explorers alike.

Outstanding Location - Positioned strategically in the charming Monumento district, the hotel is just a short stroll from vibrant downtown Salta, where the rich tapestry of local culture, art, and markets awaits your discovery.

Spa Breaks - Indulge in a sanctuary of tranquility at the hotel’s spa, where soothing massages and invigorating Scottish baths promise rejuvenation that lingers long after you've left your treatment room.

Romantic Retreat - With breathtaking city views from the Terracota restaurant, every meal is transformed into a romantic experience, as candlelight flickers softly and the aroma of Italian delicacies wafts through the air, perfectly complementing the stunning sunset.

Guest Experiences - After a long day exploring the dusty roads of Salta, one guest felt like they had entered an oasis of calm upon arrival. They were immediately enveloped by the refreshing scent of eucalyptus in the lobby as they kicked off their shoes, eager to dip into the heated pool—a moment of bliss amidst their travels.

Best Luxury Hotels that guests love in Salta Wine Route

luxury hotels in Salta Wine Route
Vicente López 146, 4400 Salta, Argentina
8.9
1343 reviews
From $156

Guest Review: Good location, good size room and very clean. Staff extremely helpful especially Paula on reception.

luxury hotels in Salta Wine Route
Ruta Nacional 40, km 4340, 4427, 4427 Cafayate, Argentina
9.2
1239 reviews
From $234

Guest Review: Great bed. Huge room. beautiful location. Good breakfast.

luxury hotels in Salta Wine Route
Buenos Aires 01, 4400 Salta, Argentina
8.9
1057 reviews
From $238

Guest Review: A beautiful hotel in a prime location. The hotel is extremely clean, excellently equipped, the staff is very friendly and helpful. The pool is very well maintained. W-Lan is working good.

Other great option in Salta Wine Route

luxury hotels in Salta Wine Route
Ruta Provincial 2 Km 3, Cafayate, 4427, AR
9.8
53 reviews
From $229

Salta Wine Route Luxury Hotels on the Map

Frequently Asked Questions

For a luxurious experience with excellent spa services, consider Piattelli Wine Resort Hotel Cafayate and Grace Cafayate. Both offer upscale amenities, stunning surroundings, and rejuvenating spa treatments that perfectly complement your wine route adventure.

Yes! If you're looking for a romantic getaway, House of Jasmines Relais & Châteaux provides a charming atmosphere with beautiful landscapes. Another great option is Legado Mitico Salta Hotel Boutique, which features unique design elements and intimate settings perfect for couples.

Food lovers will appreciate Alejandro 1º Hotel, renowned for its gourmet dining options, and Hotel Almería, known for its exquisite local cuisine. Both hotels reflect the rich culinary traditions of the region, making them ideal spots for a gastronomic journey.

Family travelers can enjoy a stay at Sheraton Salta Hotel, which offers spacious rooms and activities for kids. Additionally, Casa Real Hotel is another excellent choice, providing comfortable accommodations and easy access to family-friendly attractions along the Salta Wine Route.

Definitely! For a boutique experience, look at Legado Mitico Salta Hotel Boutique, featuring personalized service and distinctive decor. Another great option is Hotel Almería, known for its stylish ambiance and contemporary design, ideal for those seeking a memorable stay.

To enjoy breathtaking views, consider Grace Cafayate, set amidst stunning vineyards, or Piattelli Wine Resort Hotel Cafayate, which boasts panoramic vistas of the surrounding mountains and valleys. Both hotels provide an unforgettable backdrop for your stay.