The 53 Best Luxury Hotels with Spa in Italy South (2026)

Some of the finest luxury hotels with spa facilities in Italy South include San Domenico Palace, Taormina, A Four Seasons Hotel, known for its stunning views and lavish spa treatments, and Regina Isabella-Resort Spa Restaurant, which combines exquisite dining with a relaxing wellness experience.

For a romantic getaway, consider Grand Hotel Timeo, A Belmond Hotel, Taormina, featuring breathtaking views of Mount Etna, or Villa Sant'Andrea, A Belmond Hotel, Taormina Mare, where you can enjoy intimate beachside dining and luxurious spa services.

Families will find Verdura Resort an ideal choice, offering spacious accommodations and a fantastic kids’ club alongside a rejuvenating spa. Another great option is Atlantis Bay - VRetreats, which features family-focused amenities and delightful spa treatments perfect for parents.

If you're looking for great value, Hotel Mediterraneo offers elegant accommodations with access to spa facilities at reasonable rates. Another affordable yet luxurious choice is Grand Hotel Royal, known for its welcoming atmosphere and soothing wellness offerings.

Food enthusiasts should not miss Grand Hotel Excelsior Vittoria, which boasts gourmet dining experiences and a superb wine cellar. Additionally, Monaci delle Terre Nere provides a unique farm-to-table culinary experience paired with luxurious spa facilities.

For stunning views along with spa luxury, Mazzarò Sea Palace - The Leading Hotels of the World offers breathtaking coastal scenery and indulgent spa services. Similarly, Hotel Belair features panoramic vistas and a serene spa environment for relaxation.