The 7 Best Luxury Hotels with Spa in Missouri (2025)

Nestled in the heart of Clayton, The Ritz-Carlton, St. Louis invites you to immerse yourself in an oasis of elegance where timeless luxury meets modern comfort. Here, every corner exudes refinement, from the grand lobby adorned with exquisite artworks to the intimate nooks perfect for whispered conversations. Whether you're planning a romantic getaway or a productive business trip, this hotel offers a sanctuary that feels both indulgently upscale and warmly welcoming.

Total Relaxation - Indulge in the serene ambiance of our spa, where the soothing scent of essential oils lingers in the air, inviting you to unwind with bespoke treatments designed to rejuvenate your spirit. Imagine sinking into a plush robe after a tranquil massage, surrounded by the calming sounds of gentle water features.

Romantic Break - For couples seeking a memorable escape, our elegantly appointed suites provide a haven of intimacy, complete with sumptuous linens and views of the charming Clayton skyline. Candlelit dinners at our renowned restaurant transform ordinary evenings into extraordinary experiences, as you savor expertly crafted dishes paired with fine wines.

Outstanding Location - Situated just moments away from cultural gems and vibrant local markets, The Ritz-Carlton serves as the perfect launchpad for exploration. After a day of adventure, return to the hotel's chic atmosphere, where laughter and camaraderie fill the air, making it easy to connect with fellow travelers.

Guest Experiences - Guests often marvel at the unexpected thoughtful touches, like finding a TV near the shower or the delightful aroma of freshly brewed coffee wafting through the halls during early mornings. One visitor recalled the warmth of the staff, who not only ensured a smooth check-in but also made them feel like old friends with their genuine smiles and personalized service.

Nestled along the banks of the Mississippi River, Four Seasons St. Louis is a sanctuary of luxury and elegance, where breathtaking views of the iconic Gateway Arch greet you from every spacious room. This upscale escape invites couples and families alike to indulge in moments of tranquility, whether it's savoring a fine Italian meal or unwinding at the full-service spa—each detail curated for an unforgettable experience.

City Style - Immerse yourself in the vibrant energy of St. Louis with chic accommodations that blend comfort and contemporary design, from plush bedding to sleek marble bathrooms featuring deep-soaking tubs perfect for relaxation after a day of exploring.

Spa Breaks - Let the soothing ambiance of the on-site spa envelop you, where the scent of essential oils wafts through the air and expert hands guide you toward total rejuvenation, leaving you feeling refreshed and utterly pampered.

Gourmet Dining - Indulge your palate at Cielo Restaurant, where each dish bursts with flavor and creativity, while the outdoor terrace beckons for sunset cocktails accompanied by delightful appetizers, creating an enchanting atmosphere to unwind under the stars.

Guest Experiences - You might find yourself captivated by the gentle hum of laughter from the adjoining terrace as you sink into plush linens and gaze out at the shimmering city lights. The attentive staff, always ready with a smile, make it feel like they knew just what you needed before you did—like that perfectly brewed cup of coffee waiting for you at breakfast.

Nestled amid the tranquil landscapes of Camdenton, The Lodge at Old Kinderhook embodies an oasis of elegance and comfort. With its modern design interwoven with rustic charm, this luxurious retreat invites couples and seekers of serenity to indulge in romantic evenings by the fireplace or leisurely afternoons lounging poolside, surrounded by lush gardens and whispering pines.

Romantic Getaway - Feel the allure of intimacy as you unwind in elegantly appointed rooms, each a sanctuary that beckons with plush linens, soft lighting, and breathtaking views of the serene landscape. The ambiance is perfectly set for those cherished moments together, whether sipping wine on your private terrace or sharing laughter over candlelit dinners.

Wellbeing Retreat - Discover revitalization at the state-of-the-art spa, where scents of essential oils fill the air, and soothing sounds create a symphony of relaxation. Guests can immerse themselves in rejuvenating treatments or simply bask in the warmth of the hot tub, enveloped by the calming sights of nature's tapestry outside.

Outdoor Adventures - Step outside and embrace the thrill of adventure with tennis courts and scenic hiking trails just moments away. Each trek unveils stunning vistas, while the brisk air invigorates your spirit; the experience captures the essence of a true escape into nature’s embrace.

Guest Experiences - One guest delighted in the sweet fragrance of freshly brewed coffee wafting through the halls each morning, setting the perfect tone for another day of exploration. As they settled onto their balcony, the peaceful sounds of nature created a serene backdrop, punctuated only by the occasional laughter from families enjoying the pools nearby.

Nestled in the heart of Kansas City, The Raphael Hotel, Autograph Collection offers an exquisite blend of historic charm and modern elegance. With its warmly lit interiors, eclectic artworks, and the gentle sound of live music wafting through the lobby, every corner invites you to pause and savor the moment, whether you're indulging in a cozy afternoon with freshly baked cookies or retreating to your luxurious room for a night of tranquility.

Romantic Getaway - Perfectly tailored for couples, this hotel is a sanctuary where intimacy reigns supreme, from candlelit dinners in the in-house restaurant to strolling hand-in-hand through the nearby Plaza's vibrant art scene.

Boutique Charm - Every detail at The Raphael whispers sophistication—think plush furnishings, elegant décor, and a unique character that transcends the ordinary, allowing guests to immerse themselves in an experience that's both cozy and chic.

Culinary Delights - Start your morning with enticing brunch options served until 2 PM, where each dish is crafted to perfection, making breakfast in bed a truly delightful experience, all while the enchanting aromas from the kitchen mingle softly with the music playing in the background.

Guest Experiences - Guests rave about the warmth that envelops them upon entering; the delightful scent of freshly baked cookies beckons from the lobby each afternoon, while the soothing sound of chilled towels being handed out at the gym adds a touch of luxury to their wellness routine.

Nestled on the shimmering shores of Lake Ozark, Camden on the Lake Resort invites you to indulge in an oasis of elegance and tranquility. The gentle lapping of water against the marina blends seamlessly with the laughter of friends gathered around the swim-up pool bar, crafting a perfect backdrop for romantic getaways or rejuvenating escapes. Each moment here is drenched in luxury, creating an inviting atmosphere that feels both exclusive and intimately welcoming.

Spa Breaks - Rejuvenate your senses at the full-service spa, where soothing aromas and tranquil music envelop you as skilled therapists guide you into blissful relaxation. Whether it’s a couples’ massage or a skin-revitalizing treatment, every experience is tailored to refresh both body and mind.

Lakeside Escape - With views that stretch endlessly over the lake, each spacious suite allows you to bask in the natural beauty of your surroundings from your private balcony. Picture yourself sipping morning coffee while soft rays of sunlight dance on the water’s surface, setting the tone for another glorious day.

Active Holiday - For those seeking adventure, water sports abound just steps away from your door. From windsurfing across the sparkling lake to savoring a thrilling ride on water skis, excitement is never far from reach, promising unforgettable memories filled with laughter and exhilaration.

Guest Experiences - As you stroll through the resort, the sound of live music wafts through the air during seasonal concerts, drawing you toward the vibrant energy of the outdoor space. Guests often remark on the comfort of their rooms, where plush beds beckon after a long day of exploration, making it easy to drift off to sleep with the gentle hum of the lake as your lullaby.

Nestled on the serene shores of Table Rock Lake, Chateau on the Lake Resort Spa and Convention Center offers an enchanting escape where luxury meets nature's beauty. With breathtaking views of the surrounding mountains and the gentle sounds of water lapping at the shore, this upscale resort invites you to unwind in elegance, whether it's a romantic getaway or a rejuvenating wellness retreat.

Lakeside Serenity - Gaze out over the glistening waters of Table Rock Lake from your spacious room, adorned with charming French-country furnishings that create a warm, inviting atmosphere. Every morning, the landscape transforms with the hues of sunrise, offering a picturesque backdrop for your stay.

Culinary Delights - Savor exquisite American cuisine at the Chateau Grille, where each dish is crafted with fresh, local ingredients and paired with a thoughtfully curated wine selection. Alternatively, indulge in the casual elegance of the Atrium Café, where the aroma of freshly brewed coffee mingles with the gentle chatter of fellow guests enjoying delightful patio-style dining.

Spa Retreat - At Spa Chateau, immerse yourself in a world of relaxation, where soothing massages and luxurious body treatments melt away the stresses of everyday life. The tranquil ambiance, accentuated by soft music and calming scents, sets the perfect stage for total rejuvenation and self-care.

Guest Experiences - A family relished watching a dazzling fireworks display from their balcony, the vibrant colors reflecting on the lake as laughter filled the air. Meanwhile, another guest was enchanted by the friendly staff who would check in with thoughtful texts, ensuring every moment felt personalized and special.

Nestled on the serene shores of Lake Hamilton, Lookout Point Lakeside Inn offers an enchanting escape where tranquility embraces luxury. With breathtaking views that whisper romance and sophistication, this upscale haven is perfect for couples seeking intimate moments or solo travelers yearning for rejuvenation amid nature's beauty.

Romantic Retreat - Every room at Lookout Point boasts sweeping lake vistas, with plush bedding and elegant decor creating a sanctuary for lovebirds. Imagine waking up to soft sunlight spilling through large windows, beckoning you to sip coffee on your private balcony while the world awakens.

Total Relaxation - Take a leisurely stroll through our lush gardens, where tranquil waterfalls harmonize with the gentle lapping of the lake against the shore. The air is rich with the sweet scent of blooming flowers, inviting you to pause and savor the moment in a secluded nook—your own personal escape.

Culinary Delights - Indulge in a gourmet breakfast crafted from locally-sourced ingredients, where the aroma of freshly brewed coffee mingles with the warmth of homemade pastries. As you relish each bite, the picturesque backdrop of the lake enhances every delicious morsel, making breakfast an experience to cherish.

Guest Experiences - Guests often reminisce about finding their favorite spot—a chair by the lake where they could lose themselves in the stunning views and soothing sounds. One visitor noted how they felt completely pampered as the staff went above and beyond, offering heartfelt recommendations for local adventures, ensuring every moment was steeped in care.