The 6 Best Luxury Hotels with Spa in Key West (2025)

Nestled among lush tropical foliage, The Gardens Hotel is a serene adult-only retreat in the heart of Key West, where each moment feels like an intimate escape. With fragrant blooms filling the air and the gentle sound of rustling leaves, this upscale haven invites couples and romantic travelers to unwind in its elegant ambiance, just steps away from the vibrant pulse of Duval Street.

Romantic Retreat - With private balconies overlooking verdant gardens, every room at The Gardens Hotel offers a tranquil space to bask in the romance of island life. The soft whisper of palm fronds swaying creates a soothing backdrop for candlelit evenings and leisurely mornings.

Charming Oasis - Two inviting outdoor pools beckon you to lounge under the sun or find solace in shaded nooks, while the property’s hidden hammocks offer perfect spots for afternoon daydreams. Guests often delight in discovering quiet corners, making it feel like a personal sanctuary amidst the lively surroundings.

Live Entertainment - Every Sunday evening, immerse yourself in the soulful sounds of live jazz as it serenades the garden, creating a magical atmosphere that enhances the romantic setting. The enchanting melodies blend seamlessly with the evening breeze, painting memories that linger long after your stay.

Guest Experiences - As you sip coffee by the poolside, the aroma of freshly prepared breakfast wafts through the air, teasing your senses with promises of delightful flavors. A chance encounter with the gracious owner adds a personal touch, leaving guests feeling not just welcomed but truly at home in this beautiful, immaculately kept oasis.

Nestled on the sun-kissed shores of Key West, Ocean Key Resort & Spa offers an exquisite blend of luxury and tranquility, enveloped by the sounds of gentle waves and the scent of salty sea air. Here, each moment invites you to unwind, whether you're sipping a cocktail as the sun sinks into the Gulf or indulging in a rejuvenating spa treatment while the world drifts away.

Romantic Escape - With breathtaking sunset views from every corner, this resort is the epitome of romance. Stroll hand-in-hand along the Sunset Pier, where the golden hues ignite the sky, creating a backdrop that feels almost otherworldly.

Total Relaxation - Experience pure bliss at SpaTerre, where skilled therapists transport you to a sanctuary of serenity. The soothing scents of essential oils mingle with the freshness of ocean breezes, inviting you to leave your worries behind.

Culinary Delights - Savor freshly caught seafood paired with handcrafted cocktails at Hot Tin Roof, whose vibrant ambiance is enhanced by the sound of laughter and clinking glasses, reminding you that every meal here is a celebration.

Guest Experiences - One evening, a couple found themselves mesmerized by the brilliant sunset, their laughter mingling with the soft rustle of palm leaves as they shared a Cozy dinner at the waterfront. Their server surprised them with a complimentary dessert, igniting a spontaneous toast to love and life, all under the enchanting glow of twilight.

Nestled just a block away from the shimmering Atlantic Ocean and the vibrant pulse of Duval Street, Santa Maria Suites Resort is an intimate oasis that blends modern luxury with the charming quirks of Key West. Here, spacious all-suite accommodations invite you to unwind in style, surrounded by lush gardens and the gentle sound of water lapping at nearby shores, creating an atmosphere ripe for romance and relaxation.

Romantic Retreat - Indulge in the ultimate romantic escape, where each suite offers stunning decor and a full kitchen, perfect for intimate dinners or lazy breakfasts in bed, complemented by the scent of fresh muffins wafting through your door each morning.

Total Relaxation - Two heated outdoor pools beckon for leisurely dips amidst tropical gardens, while complimentary poolside smoothies refresh your spirit under the warm Florida sun—a dreamy backdrop for unwinding after exploration.

Outstanding Location - Just moments from historic sites and local markets, you can easily stroll to iconic attractions like the Ernest Hemingway House, returning to the sanctuary of your suite equipped with everything you need—truly a hub for cultural explorers and adventure seekers alike.

Guest Experiences - Guests have delighted in the unexpected treats awaiting them daily: imagine opening your suite to the allure of freshly baked muffins alongside Dove ice cream mini bars, while the friendly staff members, particularly Matilda, go above and beyond, offering personalized tips on dining and sights with genuine warmth.

Nestled along the stunning coastline of Marathon in the Florida Keys, Isla Bella Beach Resort & Spa invites you to indulge in a luxurious escape where tropical elegance meets serene seclusion. With its private stretch of pristine beach and lush gardens, every moment spent here feels like a personal retreat, wrapped in the soothing sounds of gentle waves lapping against the shore.

Beach Life - Immerse yourself in the vibrant hues of the ocean as you lounge on soft sands or enjoy thrilling water sports. The resort's exclusive beachfront is perfect for sun-soaked days filled with paddleboarding alongside playful manatees or an exhilarating jetski adventure under the sun.

Spa Breaks - Discover your sanctuary at the wellness center, where the air is infused with calming aromas and the sound of bubbling hot tubs invites relaxation. Unwind with holistic treatments that rejuvenate both body and spirit, ensuring a blissful escape from the everyday hustle.

Culinary Delights - Savor exquisite flavors at the in-house restaurant, where Hawaiian Regional Cuisines come alive with fresh, local ingredients. Each dish tells a story—imagine the aroma of grilled fish kissed by citrus as it mingles with laughter and clinking glasses, creating the perfect backdrop for romantic evenings.

Guest Experiences - One guest recalled how the warm breeze carried the scent of salt and coconut, making their morning coffee feel like a tropical ritual; while another delighted in the surprise encounter with dolphins during an afternoon paddleboarding session, turning an ordinary day into a memorable adventure.

Nestled on the sun-kissed shores of Marco Island, the JW Marriott Beach Resort stands as a bastion of luxury and serenity. With each wave lapping at the pristine shoreline, this elegant oasis invites you to indulge in a world where your every desire is met with impeccable service and breathtaking views of the Gulf of Mexico.

Total relaxation - Immerse yourself in tranquility at the Spa by JW®, where the air is infused with soothing aromas and the gentle sound of water evokes a sense of calm as skilled therapists work their magic to rejuvenate your body and spirit.

Romantic Break - Bask in the golden glow of sunset from your private balcony, where the vibrant hues of the sky create a picturesque backdrop for intimate evenings spent savoring fine wines and delectable dishes, handpicked from the resort's diverse culinary offerings.

Beach Life - Step onto the soft sands just steps from your door, where the rhythmic lull of the ocean mingles with laughter and the playful splash of families enjoying the outdoor pools—each moment a reminder that paradise is within reach.

Guest Experiences - As you lounge by the pool, the gentle breeze carries the tantalizing scent of grilled seafood, and friendly staff members glide past, ensuring your glass is never empty while the sun dips lower, inviting you to lose track of time amidst the serenity.

Nestled along the serene shores of Naples Bay, the Naples Bay Resort and Marina is a sanctuary where luxury meets tranquility. Picture yourself savoring captivating sunsets from your private balcony, enveloped in the soothing sounds of gentle waves lapping against the marina, while lush tropical gardens create an oasis of peace just minutes from vibrant downtown Naples.

Romantic Getaway - Indulge in intimate moments with breathtaking views, as each elegantly appointed room offers a personal haven overlooking the sparkling marina or serene waterways, perfect for couples seeking a romantic escape.

Spa & Relaxation - Rejuvenate your senses at The Spa at Naples Bay Resort, where herbal bath soaks and expert massages transport you to a world of bliss, inviting you to unwind amidst the tranquil ambiance enhanced by soft melodies and fragrant aromas.

Outdoor Adventures - Explore the natural beauty of Naples through exciting outdoor activities, whether it's sailing across the shimmering bay, paddling along the Curlew Canal, or cycling through scenic trails – every adventure is effortlessly accessible from your luxurious base.

Guest Experiences - Imagine waking up to the gentle rustle of palm leaves and the sweet scent of fresh pastries wafting from the Café on the Bay, where guests gather over spirited conversations and specialty coffee, all while relishing the warmth of exceptional, friendly service that makes each stay unforgettable.