The 5 Best Luxury Hotels with Spa in Departamento De Santa Cruz (2025)

Nestled in the vibrant heart of Santa Cruz de la Sierra, the Marriott Santa Cruz de la Sierra Hotel offers a sanctuary of elegance and comfort, where contemporary design meets Bolivian warmth. Picture yourself unwinding by the shimmering outdoor pool, the scent of tropical blossoms drifting through the air, as attentive staff anticipate your every need, ensuring a stay that feels both indulgent and intimate.

Spa & Relaxation - Escape to serene bliss with the hotel's spa offerings, where soothing aromas and gentle sounds envelop you during rejuvenating treatments designed for ultimate relaxation.

Outstanding Location - Conveniently positioned near shopping malls and local attractions, this hotel serves as an inviting launchpad for cultural explorers eager to delve into the rich tapestry of Bolivian life, all within a short stroll or taxi ride.

Culinary Delights - Indulge in a sumptuous breakfast that awakens your senses, featuring fresh local ingredients and aromatic coffee, providing the perfect start to your day—or simply savoring moments of quiet over a delightful meal at the on-site restaurant.

Guest Experiences - Guests have relished in the personalized touch of the staff, often recounting how they were greeted with genuine smiles and a warm cup of coffee upon check-in, creating an inviting atmosphere that lingers long after their stay.

Nestled in the vibrant heart of Santa Cruz de la Sierra, Hotel Cortez invites you to indulge in an oasis of elegance and tranquility. With lush gardens framing a sparkling outdoor pool, every moment here is steeped in sophistication and serenity, making it the perfect retreat for romantic getaways and leisurely escapes alike.

Romantic Retreat - Each spacious room is not just a stay but a sanctuary, where soft linens whisper comfort and the air carries the delicate scent of tropical blooms, setting the stage for intimate evenings.

Total Relaxation - The on-site spa beckons with the promise of rejuvenation, where gentle melodies drift through the air as skilled hands melt away tension, immersing you in blissful tranquility.

Outstanding Location - Just a short stroll from Monseñor Rivero Boulevard, immerse yourself in local culture and cuisine, or take a leisurely walk to the iconic 24 de Septiembre Square, blending exploration with convenience.

Guest Experiences - Imagine savoring a sumptuous breakfast under a sweet-scented garden canopy, the sun warming your skin while the sound of laughter from nearby guests fills the air. A helpful staff member quickly resolved a key issue, their sincere apology underscoring the genuine hospitality that makes you feel right at home.

Nestled within the vibrant heart of Santa Cruz de la Sierra, Hotel Camino Real offers a sanctuary where elegance and comfort converge. With its exquisite architecture and lush surroundings, this hotel creates an intimate atmosphere ideal for romantic getaways and serene retreats alike, inviting you to indulge in moments where luxury meets genuine Bolivian hospitality.

Spa Retreat - Immerse yourself in a haven of tranquility at the hotel's spa, where the soothing aroma of essential oils mingles with the soft sound of water trickling from the hot tub. Guests revel in rejuvenating massages and the warmth of the sauna, leaving them refreshed and revitalized after a day of exploration.

Culinary Delights - Savor the culinary artistry at La Tranquera and Novo Cafe Lounge, where each dish is crafted using fresh, local ingredients that awaken your taste buds. The breakfast spread, featuring a selection of artisanal breads and the creamiest natural yogurt, sets the perfect tone for your day ahead.

Lush Poolside Bliss - Relax in style at the outdoor swimming pool, complete with a fun water slide and a chic wet bar. Here, the laughter of friends combined with the gentle splash of water creates a lively atmosphere, while plush loungers invite you to bask under the Bolivian sun with a refreshing cocktail in hand.

Guest Experiences - As you step into the lobby, the cool marble beneath your feet feels luxurious against your skin, while the modern décor captivates your senses. A welcoming drink awaits you, perfectly chilled, as friendly staff exude warmth, making you feel instantly at home in this elegant escape.

Nestled amidst lush gardens and vibrant flora, Los Tajibos in Santa Cruz de la Sierra presents an oasis of elegance and tranquility. With a seamless blend of modern luxury and Bolivian charm, this boutique hotel invites guests to indulge in an enchanting escape where every detail whispers serenity and sophistication.

Total Relaxation - Surrender to the serene ambiance of the outdoor swimming pool, encircled by verdant landscaping, where the gentle rustling of leaves sets the perfect backdrop for a day of unwinding under the sun.

Spa Breaks - Experience rejuvenation at its finest in the tranquil spa, where the soothing scent of essential oils fills the air as attentive therapists tailor treatments designed to melt away stress and invite pure bliss.

Culinary Delights - Savor the exquisite flavors crafted by the hotel’s culinary team, with breakfasts that stand out; the rich aroma of fresh pastries wafts through the air, drawing you into a delightful morning ritual that many guests can’t resist extending.

Guest Experiences - Amidst the artistic decor and lush surroundings, guests have marveled at the friendly staff who greet them with genuine warmth, often going the extra mile—like surprising a honeymoon couple with a complimentary bottle of local wine, adding a special touch to their romantic getaway.

Nestled in the vibrant heart of Santa Cruz de la Sierra, Hampton by Hilton invites you to experience a world where modern elegance meets Bolivian charm. Picture yourself unwinding in luxurious comfort after an exhilarating day exploring local markets or savoring authentic cuisine, all while being enveloped in warm hospitality that makes every moment feel like a cherished memory.

Romantic Retreat - With thoughtfully designed rooms that blend sophistication with cozy intimacy, couples can find their sanctuary here, enjoying serene moments over panoramic views from the sky bar, where the sunset paints the city in hues of gold.

Culinary Delights - Start your day with an enticing buffet featuring regional flavors, where the aroma of freshly brewed coffee mingles with the scent of traditional Bolivian dishes, making breakfast not just a meal but a delightful experience to savor.

Wellness Haven - Recharge in the state-of-the-art fitness center or take leisurely strolls through the lush garden, creating a tranquil escape amidst the dynamic urban landscape—a perfect balance for wellness enthusiasts seeking rejuvenation.

Guest Experiences - Many guests have shared their delight at the friendly staff who remember their names and preferences, turning simple interactions into genuine connections. One traveler fondly recalled the rich taste of regional specialties at breakfast, accompanied by the soft clinking of cutlery and cheerful morning chatter.