The 6 Best Luxury Hotels with Spa in Buffalo (2026)

For a luxurious experience, consider Seneca Niagara Resort & Casino and White Oaks Conference & Resort Spa. Both offer exceptional spa services, top-notch amenities, and refined accommodations that define luxury in Buffalo.

If you're seeking a romantic getaway, Prince of Wales boasts a charming Victorian atmosphere, while 124 on Queen Hotel & Spa offers intimate spa packages to enhance your stay with that special someone.

Yes! Sterling Inn & Spa is known for its welcoming atmosphere and family-oriented amenities, while White Oaks Conference & Resort Spa provides activities for all ages, making it a great choice for families looking for a luxurious stay.

For foodies, Seneca Niagara Resort & Casino features a variety of upscale dining options, while 124 on Queen Hotel & Spa offers gourmet meals crafted from local ingredients, ensuring an unforgettable culinary experience during your stay.

For breathtaking views, consider staying at Seneca Niagara Resort & Casino, which overlooks the Niagara River, or Prince of Wales, located in the picturesque Niagara-on-the-Lake area, offering scenic landscapes and charming surroundings.

Boutique charm awaits you at Sterling Inn & Spa, where personalized service meets spa indulgence. Additionally, 124 on Queen Hotel & Spa provides a blend of comfort and elegance, perfect for travelers seeking a unique hotel experience.