The 11 Best Luxury Hotels in Departamento De Santa Cruz (2025)

Nestled in the vibrant heart of Santa Cruz de la Sierra, the Marriott Santa Cruz de la Sierra Hotel offers a sanctuary of elegance and comfort, where contemporary design meets Bolivian warmth. Picture yourself unwinding by the shimmering outdoor pool, the scent of tropical blossoms drifting through the air, as attentive staff anticipate your every need, ensuring a stay that feels both indulgent and intimate.

Spa & Relaxation - Escape to serene bliss with the hotel's spa offerings, where soothing aromas and gentle sounds envelop you during rejuvenating treatments designed for ultimate relaxation.

Outstanding Location - Conveniently positioned near shopping malls and local attractions, this hotel serves as an inviting launchpad for cultural explorers eager to delve into the rich tapestry of Bolivian life, all within a short stroll or taxi ride.

Culinary Delights - Indulge in a sumptuous breakfast that awakens your senses, featuring fresh local ingredients and aromatic coffee, providing the perfect start to your day—or simply savoring moments of quiet over a delightful meal at the on-site restaurant.

Guest Experiences - Guests have relished in the personalized touch of the staff, often recounting how they were greeted with genuine smiles and a warm cup of coffee upon check-in, creating an inviting atmosphere that lingers long after their stay.

Nestled in the vibrant heart of Santa Cruz de la Sierra, Hotel Cortez invites you to indulge in an oasis of elegance and tranquility. With lush gardens framing a sparkling outdoor pool, every moment here is steeped in sophistication and serenity, making it the perfect retreat for romantic getaways and leisurely escapes alike.

Romantic Retreat - Each spacious room is not just a stay but a sanctuary, where soft linens whisper comfort and the air carries the delicate scent of tropical blooms, setting the stage for intimate evenings.

Total Relaxation - The on-site spa beckons with the promise of rejuvenation, where gentle melodies drift through the air as skilled hands melt away tension, immersing you in blissful tranquility.

Outstanding Location - Just a short stroll from Monseñor Rivero Boulevard, immerse yourself in local culture and cuisine, or take a leisurely walk to the iconic 24 de Septiembre Square, blending exploration with convenience.

Guest Experiences - Imagine savoring a sumptuous breakfast under a sweet-scented garden canopy, the sun warming your skin while the sound of laughter from nearby guests fills the air. A helpful staff member quickly resolved a key issue, their sincere apology underscoring the genuine hospitality that makes you feel right at home.

Nestled within the vibrant heart of Santa Cruz de la Sierra, Hotel Camino Real offers a sanctuary where elegance and comfort converge. With its exquisite architecture and lush surroundings, this hotel creates an intimate atmosphere ideal for romantic getaways and serene retreats alike, inviting you to indulge in moments where luxury meets genuine Bolivian hospitality.

Spa Retreat - Immerse yourself in a haven of tranquility at the hotel's spa, where the soothing aroma of essential oils mingles with the soft sound of water trickling from the hot tub. Guests revel in rejuvenating massages and the warmth of the sauna, leaving them refreshed and revitalized after a day of exploration.

Culinary Delights - Savor the culinary artistry at La Tranquera and Novo Cafe Lounge, where each dish is crafted using fresh, local ingredients that awaken your taste buds. The breakfast spread, featuring a selection of artisanal breads and the creamiest natural yogurt, sets the perfect tone for your day ahead.

Lush Poolside Bliss - Relax in style at the outdoor swimming pool, complete with a fun water slide and a chic wet bar. Here, the laughter of friends combined with the gentle splash of water creates a lively atmosphere, while plush loungers invite you to bask under the Bolivian sun with a refreshing cocktail in hand.

Guest Experiences - As you step into the lobby, the cool marble beneath your feet feels luxurious against your skin, while the modern décor captivates your senses. A welcoming drink awaits you, perfectly chilled, as friendly staff exude warmth, making you feel instantly at home in this elegant escape.

Nestled amidst lush gardens and vibrant flora, Los Tajibos in Santa Cruz de la Sierra presents an oasis of elegance and tranquility. With a seamless blend of modern luxury and Bolivian charm, this boutique hotel invites guests to indulge in an enchanting escape where every detail whispers serenity and sophistication.

Total Relaxation - Surrender to the serene ambiance of the outdoor swimming pool, encircled by verdant landscaping, where the gentle rustling of leaves sets the perfect backdrop for a day of unwinding under the sun.

Spa Breaks - Experience rejuvenation at its finest in the tranquil spa, where the soothing scent of essential oils fills the air as attentive therapists tailor treatments designed to melt away stress and invite pure bliss.

Culinary Delights - Savor the exquisite flavors crafted by the hotel’s culinary team, with breakfasts that stand out; the rich aroma of fresh pastries wafts through the air, drawing you into a delightful morning ritual that many guests can’t resist extending.

Guest Experiences - Amidst the artistic decor and lush surroundings, guests have marveled at the friendly staff who greet them with genuine warmth, often going the extra mile—like surprising a honeymoon couple with a complimentary bottle of local wine, adding a special touch to their romantic getaway.

Nestled in the vibrant heart of Santa Cruz de la Sierra, Alfonsina Hotel Boutique beckons discerning travelers with its blend of modern elegance and intimate charm. Here, each moment is an invitation to indulge in luxurious comfort, whether you are sipping a morning latte on your private balcony or basking by the glistening outdoor pool under the Bolivian sun.

City Style - Experience the dynamic pulse of Equipetrol, where artful décor meets urban sophistication, and every corner showcases thoughtful design that resonates with the local culture.

Total Relaxation - Unwind in the serene embrace of our lush outdoor spaces, where the gentle sound of water from the pool mingles with soothing melodies, creating a sanctuary for rejuvenation and tranquility.

Romantic Break - Alfonsina is the perfect backdrop for romance; share candlelit dinners at nearby restaurants or take leisurely strolls through charming streets, all while enveloped in a sense of privacy and intimacy.

Guest Experiences - Imagine waking up to the aroma of freshly brewed coffee wafting through your room, the inviting warmth of plush linens beneath you, as you step onto the balcony to catch glimpses of city life unfolding below—this is the true essence of a stay at Alfonsina.

Nestled in the vibrant heart of Santa Cruz de la Sierra, Novotel Santa Cruz De La Sierra is a sanctuary where modern luxury effortlessly meets Bolivian charm. With its sleek design and inviting spaces, this hotel invites couples, wellness enthusiasts, and cultural explorers to unwind within an atmosphere rich in comfort and style, ensuring that every moment feels like a serene escape from the bustling city life.

City Style - Embrace the urban allure of Santa Cruz as you step outside the chic confines of the hotel. Local markets and historical treasures are just moments away, offering guests a unique opportunity to immerse themselves in the city's vibrant culture and warmth.

Total Relaxation - Dive into tranquility at the hotel’s outdoor swimming pool or unwind in the hot tub, where warm bubbles soothe the senses amidst lush greenery. Each corner of this space beckons for peaceful moments, allowing you to bask in the gentle Bolivian sun while sipping a refreshing drink.

5* Luxury - Experience unparalleled luxury with elegantly designed rooms equipped with plush amenities. From the aroma of freshly brewed coffee in your own space to the delightful buffet breakfast that lays out a feast of local flavors, every detail is curated to elevate your stay into a realm of indulgence.

Guest Experiences - As the sun dipped below the horizon, a guest reveled in the playful laughter of children enjoying the well-appointed kids' club while savoring a thoughtfully crafted meal at the restaurant. The warm, welcoming smiles of the staff, including Enrique at the front desk, added a personal touch, making it feel like a home away from home.

Nestled in the heart of Santa Cruz de la Sierra, Cosmopolitano Hotel Boutique beckons with its intimate charm and sophisticated ambiance. Each corner of this haven radiates warmth and artistry, enveloping guests in a serene escape where contemporary elegance meets Bolivian history.

Artworks & Local Exploring - Vibrant artworks grace the walls of this chic boutique hotel, each piece narrating a tale of local culture. Just a short stroll away, immerse yourself in the rich tapestry of nearby museums, where the essence of Bolivia's artistic heritage comes alive.

Romantic Break - With its inviting patios bathed in natural light, this romantic retreat offers endless opportunities for whispered secrets and stolen glances. The soothing sound of water splashing from the outdoor pool creates a tranquil backdrop, perfect for couples seeking a serene getaway.

Total Relaxation - From leisurely mornings spent lounging by the pool to evenings indulging in culinary delights at the quaint cafe, every moment here is designed for unwinding. Experience true comfort in rooms equipped with plush bedding and thoughtful amenities that make you feel right at home.

Guest Experiences - Imagine waking to the aroma of freshly brewed coffee wafting through the air, complemented by a breakfast spread that exceeded expectations—complete with crispy bacon and fluffy gluten-free toast. Guests have cherished the attentive staff, particularly Valeria, who effortlessly navigated their requests while sharing delightful recommendations for nearby adventures.

Nestled in the vibrant heart of Santa Cruz de la Sierra, Apart Hotel TOBOROCHI offers a tranquil escape where tropical elegance meets modern comfort. The inviting outdoor pool glimmers under the Bolivian sun, surrounded by lush gardens that whisper tales of relaxation and indulgence, creating an oasis for couples and solo travelers alike.

Spa & Relaxation - Immerse yourself in sheer bliss at our serene sauna and unwind beside the shimmering outdoor pool, where the air is infused with the scent of blooming tropical flowers—a true sanctuary for wellness enthusiasts seeking total rejuvenation.

Outstanding Location - Conveniently located just moments from the lively Plaza 24 de Septiembre, explore local markets and indulge in the rich culture of Santa Cruz, while enjoying sunset strolls along charming streets that pulse with life and history.

Romantic Break - Perfect for honeymooners, our elegantly furnished suites invite you to bask in intimate moments, complete with a cozy seating area and a well-stocked mini-bar, ideal for toasting under a starlit sky on your private terrace.

Guest Experiences - Upon arrival, the warm welcome enveloped guests like a favorite blanket, with the doorman's friendly banter echoing in the lobby, paired with the rich aroma of fresh coffee emanating from the nearby café—each detail crafting a sense of belonging.

Nestled in the vibrant heart of Santa Cruz de la Sierra, Hampton by Hilton invites you to experience a world where modern elegance meets Bolivian charm. Picture yourself unwinding in luxurious comfort after an exhilarating day exploring local markets or savoring authentic cuisine, all while being enveloped in warm hospitality that makes every moment feel like a cherished memory.

Romantic Retreat - With thoughtfully designed rooms that blend sophistication with cozy intimacy, couples can find their sanctuary here, enjoying serene moments over panoramic views from the sky bar, where the sunset paints the city in hues of gold.

Culinary Delights - Start your day with an enticing buffet featuring regional flavors, where the aroma of freshly brewed coffee mingles with the scent of traditional Bolivian dishes, making breakfast not just a meal but a delightful experience to savor.

Wellness Haven - Recharge in the state-of-the-art fitness center or take leisurely strolls through the lush garden, creating a tranquil escape amidst the dynamic urban landscape—a perfect balance for wellness enthusiasts seeking rejuvenation.

Guest Experiences - Many guests have shared their delight at the friendly staff who remember their names and preferences, turning simple interactions into genuine connections. One traveler fondly recalled the rich taste of regional specialties at breakfast, accompanied by the soft clinking of cutlery and cheerful morning chatter.

Nestled in the heart of Santa Cruz de la Sierra, Mai Suites Apart Hotel offers a symphony of modern luxury and tranquil comfort. Here, sleek contemporary design meets Bolivian warmth, creating an intimate cocoon for couples, adventurers, and business travelers alike, all while just moments away from vibrant city life.

City Style - Experience the vibrant pulse of Santa Cruz as you step outside your door, with chic boutiques, lively local markets, and enticing restaurants beckoning just a stroll away.

Total Relaxation - Our outdoor pool invites you to unwind beneath the Bolivian sun, where you can float amid fragrant blooms, absorbing the soothing sounds of nature and soft laughter from nearby guests enjoying their own peaceful retreats.

5* Luxury - Indulge in spacious accommodations designed for comfort and elegance, featuring plush furnishings, modern amenities, and well-appointed kitchens that make you feel right at home, whether you're whipping up a late-night snack or sipping coffee in your robe.

Guest Experiences - As the sun set over the bustling city, one guest was enchanted by the inviting aroma wafting from the on-site Japanese restaurant, leading them to a delightful sushi feast that became an unexpected highlight of their stay.

Nestled in the verdant heart of Santa Cruz de la Sierra, Buganvillas Hotel Suites envelops you in a world of sophisticated tranquility. With its modern design adorned by contemporary art, this boutique retreat is a sanctuary where each suite feels like a private oasis, perfect for couples seeking romance or families desiring a spacious escape.

Total relaxation - Unwind beside the shimmering pool where the gentle sound of water lapping against the edges harmonizes with the soft Bolivian breeze—a perfect spot to soak up the sun on lavish loungers while sipping a refreshing drink.

Romantic Break - Each self-catering suite offers an intimate space adorned with chic furnishings and cozy seating areas, creating an inviting ambiance where whispered conversations and laughter can flourish amidst a backdrop of vibrant artwork.

Outstanding location - Just moments away from the lively city center, yet a tranquil haven unto itself, Buganvillas allows easy access to local markets and cultural treasures while providing a serene refuge from the energetic pulse of Santa Cruz.

Guest Experiences - One guest noted how the two-bedroom suite felt more like home than a hotel, with the aroma of fresh coffee wafting through the air each morning, enhancing their sense of comfort and ease as they prepared for another day of exploration.