The 11 Best Luxury Hotels in Departamento de Santa Cruz (2026)

Top Luxury Hotels Departamento De Santa Cruz

Marriott Santa Cruz de la Sierra Hotel

Marriott Santa Cruz de la Sierra Hotel

Hotel
4to Anillo Entre Radial 23 y Calle Las Ramblas s/n, 10260 Santa Cruz de la Sierra, Bolivia
  • Spa & Relaxation
  • Outstanding Location
  • Culinary Delights
7 Baths 419.79 ft²
Hotel Cortez

Hotel Cortez

Hotel
Av. Cristobal de Mendoza 280, 9999 Santa Cruz de la Sierra, Bolivia
  • Romantic Retreat
  • Total Relaxation
  • Outstanding Location
4 Baths 296.01 ft²
Hotel Camino Real

Hotel Camino Real

Hotel
Av. San Martin Y Av. Cuarto Anillo, 2130 Santa Cruz de la Sierra, Bolivia
  • Spa Retreat
  • Culinary Delights
  • Lush Poolside Bliss
9 Baths 532.22 ft²
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Hotel
Avenida San Martin 455, Santa Cruz de la Sierra, Bolivia
  • Total Relaxation
  • Spa Breaks
  • Culinary Delights
11 Baths 371.84 ft²
Alfonsina Hotel Boutique

Alfonsina Hotel Boutique

Hotel
Alfonsina Storni #12, Equipetrol, 9999 Santa Cruz de la Sierra, Bolivia
  • City Style
  • Total Relaxation
  • Romantic Break
5 Baths 889.82 ft²
Novotel Santa Cruz De La Sierra

Novotel Santa Cruz De La Sierra

Hotel
Av. Roca Coronado 901 entre tercer y cuarto anillo, 1823 Santa Cruz de la Sierra, Bolivia
  • City Style
  • Total Relaxation
  • 5* Luxury
7 Baths 344.45 ft²
Cosmopolitano Hotel Boutique

Cosmopolitano Hotel Boutique

Hotel
Calle Pari #70 Entre René Moreno y Independencia, Santa Cruz de la Sierra, Bolivia
  • Artworks & Local Exploring
  • Romantic Break
  • Total Relaxation
6 Baths 269.1 ft²
Apart Hotel TOBOROCHI

Apart Hotel TOBOROCHI

Hotel
Jaime Freyre 7 , 9999 Santa Cruz de la Sierra, Bolivia
  • Spa & Relaxation
  • Outstanding Location
  • Romantic Break
5 Baths 888.02 ft²
Hampton by Hilton Santa Cruz

Hampton by Hilton Santa Cruz

Hotel
San Martin Avenue Esq., Street E-Eq, 0000000 Santa Cruz de la Sierra, Bolivia
  • Romantic Retreat
  • Culinary Delights
  • Wellness Haven
1 Baths 271.25 ft²
Mai Suites Apart Hotel

Mai Suites Apart Hotel

Hotel
Calle los Pino #522 esquina Los Lirios Zona Equipetrol cuarto anillo, 2512 Santa Cruz de la Sierra, Bolivia
  • City Style
  • Total Relaxation
  • 5* Luxury
7 Baths 837.79 ft²
Buganvillas Hotel Suites

Buganvillas Hotel Suites

Hotel
Av. Roca y Coronado 901 , 2218 Santa Cruz de la Sierra, Bolivia
  • Total Relaxation
  • Romantic Break
  • Outstanding Location
8 Baths 1342.8 ft²

Best Luxury Hotels that guests love in Departamento De Santa Cruz

boutique hotels in Departamento De Santa Cruz
Calle Pari #70 Entre René Moreno y Independencia, Santa Cruz de la Sierra, Bolivia
9.1
1112 reviews
From $80

Guest Review: Amazing hospitality from the staff here, especially Valeria who we interacted with most during our stay. She has been very helpful and friendly :)! We really liked what they did here with the rooms and common areas, very thoughtful design and we felt like we were in an oasis! We had stayed here for 2 nights and wouldn't mind it to be longer 👍🏻

boutique hotels in Departamento De Santa Cruz
Av. San Martin Y Av. Cuarto Anillo, 2130 Santa Cruz de la Sierra, Bolivia
8.9
543 reviews
From $98

Guest Review: Gorgeous property, beautifully appointed rooms, lots of space, clean, quiet, luxurious. Great spa.

boutique hotels in Departamento De Santa Cruz
Avenida San Martin 455, Santa Cruz de la Sierra, Bolivia
8.8
493 reviews
From $133

Guest Review: It was amazing the staff were awesome. The breakfast was amazing and you’re ever need was looked after by the people who were there couldn’t tell you that I’ve ever been the cleaner place..

Other great option in Departamento De Santa Cruz

boutique hotels in Departamento De Santa Cruz
Condominio Berchatti Norte I Apartamento 06, piso 2, Condominio Berchatti Norte I, Santa Cruz de la Sierra, BO
9.1
8 reviews
From $21

Frequently Asked Questions

The top luxury hotels in Departamento de Santa Cruz include Marriott Santa Cruz de la Sierra Hotel, known for its world-class amenities and elegant design, and Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel, which offers beautiful gardens and exceptional service. For a blend of luxury and local charm, consider Hotel Cortez.

Yes, for a romantic getaway, consider Hotel Camino Real, which features luxurious rooms and serene surroundings. Another great option is Alfonsina Hotel Boutique, perfect for couples looking for a cozy escape with personalized services.

Food lovers will appreciate Buganvillas Hotel Suites, known for its gourmet dining options, and Novotel Santa Cruz De La Sierra, which offers a diverse menu featuring local and international cuisine. Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel also impresses with its exquisite culinary offerings.

For breathtaking views in Departamento de Santa Cruz, Hampton by Hilton Santa Cruz offers panoramic vistas from its modern accommodations. Additionally, Mai Suites Apart Hotel provides guests with picturesque views of the cityscape and surrounding landscapes.

Absolutely! Marriott Santa Cruz de la Sierra Hotel features family suites and kid-friendly amenities. Another excellent choice is Buganvillas Hotel Suites, offering spacious rooms and outdoor activities that cater to families traveling together.

For those seeking boutique experiences, Cosmopolitano Hotel Boutique combines unique design with personalized service, while Alfonsina Hotel Boutique provides an intimate atmosphere and charming decor, making them ideal choices for travelers craving something special.